Focus Issue: Wnt and β-Catenin Signaling in Development and Disease

被引：75

作者：

Gough, Nancy R. ^{[1
]}

机构：

[1] Amer Assoc Advancement Sci, Washington, DC 20005 USA

来源：

SCIENCE SIGNALING | 2012年 / 5卷 / 206期

关键词：

D O I：

10.1126/scisignal.2002806

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The Wnt pathways represent key signaling networks involved in development, both in tissue specification and in cellular migration. Wnt signaling also plays key roles in tissue homeostasis in adult animals, and aberrant Wnt signaling is associated with several forms of cancer. This issue includes descriptions of a proapoptotic function for Wnt signaling in melanoma, an interplay between Wnt and bone morphogenetic proteins in tooth organogenesis, and a noncanonical role for Wnt in neuronal guidance.

引用

页数：2

共 25 条

[1]

Biechele T.L., Kulikauskas R.M., Toroni R.A., Lucero O.M., Swift R.D., James R.G., Robin N.C., Dawson D.W., Moon R.T., Chien A.J., Wnt/β-catenin signaling and AXIN1 regulate apoptosis triggered by inhibition of the mutant kinase BRAF <sup>V600E</sup> in human melanoma, Sci. Signal., 5, (2012)

[2]

O'Connell D.J., Ho J.W.K., Mammoto T., Turbe-Doan A., O'Connell J.T., Haseley P.S., Koo S., Kamiya N., Ingber D.E., Park P.J., Maas R.L., A Wnt-Bmp feedback circuit controls intertissue signaling dynamics in tooth organogenesis, Sci. Signal., 5, (2012)

[3]

Luckert K., Gujral T.S., Chan M., Joos T.O., Sorger P.K., MacBeath G., Potz O., A dual array-based approach to assess the abundance and posttranslational modifi cation state of signaling proteins, Sci. Signal., 5, (2012)

[4]

Hutchins B.I., Li L., Kalil K., Wntinduced calcium signaling mediates axon growth and guidance in the developing corpus callosum, Sci. Signal., 5, (2012)

[5]

Biechele T.L., Chien A.J., Moon R.T., VanHook A.M., Science Signaling Podcast: 10 January 2012, Sci. Signal., 5, (2012)

[6]

Akiyama H., Matsu-ura T., Mikoshiba K., Kamiguchi H., Control of neuronal growth cone navigation by asymmetric inositol 1,4,5-trisphosphate signals, Sci. Signal., 2, (2009)

[7]

Jacob L.S., Wu X., Dodge M.E., Fan C.-W., Kulak O., Chen B., Tang W., Wang B., Amatruda J.F., Lum L., Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling, Sci. Signal., 4, (2011)

[8]

Kim N.H., Kim H.S., Kim N.-G., Lee I., Choi H.-S., Li X.-Y., Kang S.E., Cha S.Y., Ryu J.K., Na J.M., Park C., Kim K., Lee S., Gumbiner B.M., Yook J.I., Weiss S.J., P53 and microRNA-34 are suppressors of canonical Wnt signaling, Sci. Signal., 4, (2011)

[9]

Eivers E., Demagny H., Choi R.H., De Robertis E.M., Phosphorylation of Mad controls competition between Wingless and BMP signaling, Sci. Signal., 4, (2011)

[10]

Wexler E.M., Rosen E., Lu D., Osborn G.E., Martin E., Raybould H., Geschwind D.H., Genome-wide analysis of a Wnt1-regulated transcriptional network implicates neurodegenerative pathways, Sci. Signal., 4, (2011)

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