Differences between hereditary and sporadic ovarian cancer

被引：11

作者：

Zweemer, RP ^{[1
]}

Verheijen, RHM

Menko, FH

Gille, JJP

van Diest, PJ

Coebergh, JW

Shaw, PA

Jacobs, IJ

Kenemans, P

机构：

[1] St Bartholomews Hosp, Gynaecol Canc Res Unit, London, England

[2] Vrije Univ Amsterdam, Univ Hosp, Dept Obstet & Gynaecol, Amsterdam, Netherlands

[3] Vrije Univ Amsterdam, Univ Hosp, Dept Clin Genet, Amsterdam, Netherlands

[4] Vrije Univ Amsterdam, Univ Hosp, Dept Pathol, Amsterdam, Netherlands

[5] IKZ, Comprehens Canc Ctr S, Eindhoven, Netherlands

[6] Univ Toronto, Sunnybrook Hlth Sci Ctr, Div Anat Pathol, Toronto, ON, Canada

来源：

EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY | 1999年 / 82卷 / 02期

关键词：

ovarian cancer; hereditary; molecular genetics; BRCA1;

D O I：

10.1016/S0301-2115(98)00218-8

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Approximately 5% of ovarian cancer cases can be attributed to an autosomal dominant inheritance factor. The majority of these cases are due to germline mutations in the BRCA1 or BRCA2 tumoursupressor genes. Patients with hereditary disease do not exhibit pathognomonic features that would allow distinction from non-hereditary (sporadic) cases of ovarian cancer. Our studies are aimed at identifying clinical, histopathological as well as molecular genetic differences between hereditary and sporadic ovarian cancer. Clinical studies of the ovarian cancer cases in 31 families revealed differences regarding age at onset and stage as well as in survival compared with cancer registry controls. The molecular studies of hereditary ovarian cancer are still underway and some preliminary data is discussed. (C) 1999 Published by Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：151 / 153

页数：3

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