Arene cis-dihydrodiols:: Useful precursors for the preparation of analogues of the anti-tumour agent, 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC)

被引：14

作者：

Arthurs, Claire L.

Raftery, James

Whitby, Helen L.

Whitehead, Roger C. ^{[1
]}

Wind, Natasha S.

Stratford, Ian J.

机构：

[1] Univ Manchester, Sch Chem, Manchester M13 9PL, Lancs, England

[2] Univ Manchester, Sch Pharm & Pharmaceut Sci, Manchester M13 9PL, Lancs, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 21期

基金：

英国医学研究理事会;

关键词：

glutathione; glutathione transferase; anti-tumour; COTC;

D O I：

10.1016/j.bmcl.2007.07.070

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of 6-epi-COTC, a diastereoisomer of Streptomyces metabolite 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC), is described. The anti-cancer activities of the novel analogue, in racemic and enantiomerically pure forms, are presented. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：5974 / 5977

页数：4

共 27 条

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