Successful engraftment of a second transplant using non-myeloablative conditioning as treatment for graft failure following unrelated donor BMT

被引：3

作者：

Byrne, JL ^{[1
]}

Musuka, C ^{[1
]}

Davy, B ^{[1
]}

Donovan, L ^{[1
]}

Russell, NH ^{[1
]}

机构：

[1] City Hosp Nottingham, Dept Haematol, Nottingham NG5 1PB, England

来源：

BONE MARROW TRANSPLANTATION | 2001年 / 27卷 / 05期

关键词：

graft failure; MUD BMT; second transplant; non-myeloablative conditioning;

D O I：

10.1038/sj.bmt.1702825

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

A 32-year-old man with CML in second chronic phase developed primary graft failure following matched unrelated donor transplantation using cryopreserved marrow cells. He was successfully regrafted within 60 days from a second fully matched donor using a non-myeloablative conditioning regimen, with minimal toxicity. He remains in complete haematological, cytogenetic and molecular remission 2 years after second transplant, We believe that reduced intensity or 'mini-transplants' may be preferable for patients requiring second allografts which are usually associated with a high transplant-related mortality.

引用

页码：547 / 549

页数：3

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