Reactions of N-hydroxysuccinimide esters of N-alkoxycarbonyl-alpha-amino acids with active methylene compounds. Synthesis of 3-substituted tetramic acids

被引：28

作者：

Detsi, A

Markopoulos, J

IgglessiMarkopoulou, O

机构：

[1] NATL TECH UNIV ATHENS,DEPT CHEM ENGN,ORGAN CHEM LAB,GR-15773 ATHENS,GREECE

[2] UNIV ATHENS,DEPT CHEM,GR-10680 ATHENS,GREECE

来源：

CHEMICAL COMMUNICATIONS | 1996年 / 11期

关键词：

D O I：

10.1039/cc9960001323

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The N-hydroxysuccinimide esters of N-alkoxycarbonyl-alpha-amino acids react with active methylene compounds (cyanoacetic esters,malonic and acyl acetic esters), under basic conditions, to produce 3-substituted N-alkoxycarbonyl tetramic acids; in the case of the N-hydroxysuccinimide esters derived from L-aminoacids, the corresponding optically active tetramic acids are obtained.

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页码：1323 / 1324

页数：2

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