Gramicidin S production by Bacillus brevis in simulated microgravity

被引：40

作者：

Fang, A

Pierson, DL

Mishra, SK

Koenig, DW

Demain, AL

机构：

[1] MIT,DEPT BIOL,CAMBRIDGE,MA 02139

[2] NASA,JOHNSON SPACE CTR,HOUSTON,TX 77058

[3] KRUG LIFE SCI INC,HOUSTON,TX 77058

来源：

CURRENT MICROBIOLOGY | 1997年 / 34卷 / 04期

关键词：

Fermentation; Glycerol; Bacillus; Secondary Metabolism; Normal Gravity;

D O I：

10.1007/s002849900168

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In a continuing study of microbial secondary metabolism in simulated microgravity, we have examined gramicidin S (GS) production by Bacillus brevis strain Nagano in NASA High Aspect Rotating Vessels (HARVs), which are designed to simulate some aspects of microgravity, Growth and GS production were found to occur under simulated microgravity. When performance under simulated microgravity was compared with that under normal gravity conditions in the bioreactors, GS production was found to be unaffected by simulated microgravity. The repressive effect of glycerol in flask fermentations was not observed in the HARV. Thus the negative effect of glycerol on specific GS formation is dependent on shear and/or vessel geometry, not gravity.

引用

页码：199 / 204

页数：6

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