Study of apoB gene signal peptide insertion/deletion polymorphism in a healthy Serbian population: no association with serum lipid levels

被引：20

作者：

Glisic, S ^{[1
]}

Prljic, J ^{[1
]}

Radovanovic, N ^{[1
]}

Alavantic, D ^{[1
]}

机构：

[1] VINCA INST NUCL SCI, LAB RADIOBIOL & MOL GENET 080, YU-11001 BELGRADE, YUGOSLAVIA

来源：

CLINICA CHIMICA ACTA | 1997年 / 263卷 / 01期

关键词：

lipids; apoB gene; polymorphism; signal peptide; PCR;

D O I：

10.1016/S0009-8981(97)06556-X

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The apolipoprotein B (apoB) signal peptide polymorphism was studied in unrelated healthy individuals. A total of 232 women and 222 men were analyzed separately. The relative frequencies of Del allele in women and men were 0.42 and 0.37, respectively. More heterozygous individuals were detected in comparison with other populations, using a modified silver staining method on polyacrylamide gel for visualization of Ins and Del alleles. There was no statistically significant difference in mean lipid levels adjusted for age, BMI, smoking habit and blood pressure between the three Ins/Del genotypes in both samples (ANOVA). Therefore, no differences were shown in the genotype frequency distribution throughout the lipid quartiles. (C) 1997 Elsevier Science B.V.

引用

页码：57 / 65

页数：9

共 28 条

[1]

AVOGARO P, 1979, LANCET, V1, P901

[2] A UNIQUE LENGTH POLYMORPHISM IN THE SIGNAL PEPTIDE REGION OF THE APOLIPOPROTEIN-B GENE IN MEXICAN-AMERICANS [J].

BOERWINKLE, E ;

HANIS, CL ;

CHAN, L .

NUCLEIC ACIDS RESEARCH, 1990, 18 (23) :7193-7193

[3] SIGNAL PEPTIDE LENGTH VARIATION IN HUMAN APOLIPOPROTEIN-B GENE - MOLECULAR CHARACTERISTICS AND ASSOCIATION WITH PLASMA-GLUCOSE LEVELS [J].

BOERWINKLE, E ;

CHEN, SH ;

VISVIKIS, S ;

HANIS, CL ;

SIEST, G ;

CHAN, L .

DIABETES, 1991, 40 (11) :1539-1544

[4] A 3 CODON INSERTION-DELETION POLYMORPHISM IN THE SIGNAL PEPTIDE REGION OF THE HUMAN APOLIPOPROTEIN-B (APOB) GENE DIRECTLY TYPED BY THE POLYMERASE CHAIN-REACTION [J].

BOERWINKLE, E ;

CHAN, L .

NUCLEIC ACIDS RESEARCH, 1989, 17 (10) :4003-4003

[5]

BOHN M, 1994, CLIN GENET, V45, P255

[6] A RECEPTOR-MEDIATED PATHWAY FOR CHOLESTEROL HOMEOSTASIS [J].

BROWN, MS ;

GOLDSTEIN, JL .

SCIENCE, 1986, 232 (4746) :34-47

[7]

FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499

[8] THE INS DEL POLYMORPHISM IN THE SIGNAL SEQUENCE OF APOLIPOPROTEIN-B HAS NO EFFECT ON LIPID PARAMETERS [J].

GAFFNEY, D ;

FREEMAN, DJ ;

SHEPHERD, J ;

PACKARD, CJ .

CLINICA CHIMICA ACTA, 1993, 218 (02) :131-138

[9] INFLUENCE OF POLYMORPHISMS FOR APOLIPOPROTEIN-B (INS/DEL, XBAI, ECORI) AND APOLIPOPROTEIN-E ON SERUM-LIPIDS AND APOLIPOPROTEINS IN A JAVA']JAVANESE POPULATION [J].

GAJRA, B ;

CANDLISH, JK ;

SAHA, N ;

HENG, CK ;

SOEMANTRI, AG ;

TAY, JSH .

GENETIC EPIDEMIOLOGY, 1994, 11 (01) :19-27

[10] APOLIPOPROTEIN-B GENE DNA POLYMORPHISMS (ECORI AND MSPI) AND SERUM-LIPID LEVELS IN THE SERBIAN HEALTHY POPULATION - INTERACTION OF RARE ALLELES AND SMOKING AND CHOLESTEROL LEVELS [J].

GLISIC, S ;

SAVIC, I ;

ALAVANTIC, D .

GENETIC EPIDEMIOLOGY, 1995, 12 (05) :499-508

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