A metalloprotease disintegrin that controls cell migration in Caenorhabditis elegans

被引：90

作者：

Nishiwaki, K ^{[1
]}

Hisamoto, N

Matsumoto, K

机构：

[1] NEC Corp Ltd, Japan Sci & Technol Corp, PRESTO, Tsukuba, Ibaraki 3058501, Japan

[2] NEC Corp Ltd, Fundamental Res Labs, Tsukuba, Ibaraki 3058501, Japan

[3] Japan Sci & Technol Corp, CREST, Chikusa Ku, Nagoya, Aichi 4648602, Japan

[4] Nagoya Univ, Grad Sch Sci, Dept Mol Biol, Chikusa Ku, Nagoya, Aichi 4648602, Japan

来源：

SCIENCE | 2000年 / 288卷 / 5474期

关键词：

D O I：

10.1126/science.288.5474.2205

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

in Caenorhabditis elegans, the gonad acquires two U-shaped arms by the directed migration of its distal tip cells (DTCs) along the body wall basement membranes. Correct migration of DTCs requires the mig-17 gene, which encodes a member of the metalloprotease-disintegrin protein family. The MIG-17 protein is secreted from muscle cells of the body wall and Localizes in the basement membranes of gonad, This localization is dependent on the disintegrin-like domain of MIG-17 and its catalytic activity, These results suggest that the MIG-17 metalloprotease directs migration of DTCs by remodeling the basement membrane.

引用

页码：2205 / 2208

页数：4

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