The World's Experience With Facial Transplantation What Have We Learned Thus Far?

被引:107
作者
Gordon, Chad R. [1 ]
Siemionow, Maria [1 ]
Papay, Francis [1 ]
Pryor, Landon [1 ]
Gatherwright, James [1 ]
Kodish, Eric [2 ]
Paradis, Carmen [2 ]
Coffman, Kathy [3 ]
Mathes, David [4 ]
Schneeberger, Stefan [5 ]
Losee, Joseph [5 ]
Serletti, Joseph M. [6 ]
Hivelin, Mikael [7 ]
Lantieri, Laurent [7 ]
Zins, James E. [1 ]
机构
[1] Cleveland Clin, Dept Plast Surg, Cleveland, OH 44195 USA
[2] Cleveland Clin, Dept Bioeth, Cleveland, OH 44195 USA
[3] Cleveland Clin, Div Transplant Psychiat, Cleveland, OH 44195 USA
[4] Univ Washington, Div Plast Surg, Seattle, WA 98195 USA
[5] Univ Pittsburgh, Div Plast Surg, Pittsburgh, PA USA
[6] Univ Penn, Sch Med, Div Plast Surg, Philadelphia, PA 19104 USA
[7] Hop Henri Mondor, Dept Plast Surg, Paris, France
关键词
facial composite tissue allograft; composite tissue transplant; candidate selection; systematic review; immunosuppression; functional outcomes; COMPOSITE TISSUE ALLOTRANSPLANTATION; FACE; ALLOGRAFT; CLASSIFICATION;
D O I
10.1097/SAP.0b013e3181ba5245
中图分类号
R61 [外科手术学];
学科分类号
摘要
The objective of this review article is to summarize the published details and media citations for all seven face transplants performed to date to point out deficiencies in those reports so as to provide the basis for examining where the field of face transplantation stands, and to act as a stimulus to enhance the quality of future reports and functional outcomes. Overall long-term function of facial alloflaps has been reported satisfactorily ill all seven cases. Sensory recovery ranges between 3 and 6 months, and acceptable motor recovery ranges between 9 and 12 months, The risks and benefits of facial composite tissue allotransplantation, which involves mandatory lifelong immunosuppression analogous to kidney transplants, should be deliberated by each institution's multidisciplinary face transplant team. Face transplantation has been shown thus far to be a viable option in some patients suffering severe facial deficits which are not amenable to modern-day reconstructive technique.
引用
收藏
页码:572 / 578
页数:7
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