Effects of Depression and Serotonergic Antidepressants on Bone: Mechanisms and Implications for the Treatment of Depression

被引：60

作者：

Fernandes, Brisa S. ^{[1
,2
]}

Hodge, Jason M. ^{[3
,4
]}

Pasco, Julie A. ^{[1
,5
]}

Berk, Michael ^{[1
,6
]}

Williams, Lana J. ^{[1
]}

机构：

[1] Deakin Univ, Sch Med, IMPACT Strateg Res Ctr, POB 281, Geelong, Vic 3220, Australia

[2] Univ Fed Rio Grande do Sul, Dept Biochem, Lab Calcium Binding Prot Cent Nervous Syst, Porto Alegre, RS, Brazil

[3] Barwon Hlth Univ Hosp, Barwon Biomed Res, Geelong, Vic, Australia

[4] Deakin Univ, Sch Med, MMR Strateg Res Ctr, Geelong, Vic 3217, Australia

[5] Univ Melbourne, Dept Med, St Albans, Vic, Australia

[6] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Dept Psychiat & Orygen, Natl Ctr Excellence Youth Mental Hlth, Parkville, Vic 3052, Australia

来源：

DRUGS & AGING | 2016年 / 33卷 / 01期

基金：

英国医学研究理事会;

关键词：

TRANSPORTER INHIBITION EVIDENCE; REUPTAKE INHIBITORS; PSYCHIATRIC-DISORDERS; MINERAL DENSITY; RISK; MASS; EPIDEMIOLOGY; OSTEOPOROSIS; METAANALYSIS; ASSOCIATION;

D O I：

10.1007/s40266-015-0323-4

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

Osteoporosis is a chronic skeletal disease marked by microarchitectural deterioration of the bone matrix and depletion of bone mineral density (BMD), with a consequent increased risk for fragility fractures. It has been frequently associated with depression, which is also a chronic and debilitating disorder with high prevalence. Selective serotonin reuptake inhibitors (SSRIs), first-line agents in the pharmacological treatment of mood and anxiety disorders, have also been shown to negatively affect bone metabolism. SSRIs are the most prescribed antidepressants worldwide and a large number of persons at risk of developing osteoporosis, including older patients, will receive these antidepressants. Therefore, a proper musculoskeletal evaluation of individuals who are being targeted for or using SSRIs is a priority. The aim of this article is to review the evidence regarding the effects of depression and serotonergic antidepressants on bone and its implications for clinical care.

引用

页码：21 / 25

页数：5

共 47 条

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