Cytochromes P450 in brain: Function and significance

被引：59

作者：

Strobel, HW ^{[1
]}

Thompson, CM ^{[1
]}

Antonovic, L ^{[1
]}

机构：

[1] Univ Texas, Sch Med, Dept Biochem & Mol Biol, Houston, TX 77225 USA

来源：

CURRENT DRUG METABOLISM | 2001年 / 2卷 / 02期

关键词：

D O I：

10.2174/1389200013338577

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

dThe presence and activity of cytochromes P450 in brain regions and various brain cells have been extended and advanced over the last five years covered by this review. Using in situ hybridization and immunohistochemical techniques, many cytochrome P450 enzymes have been demonstrated to be present in brain and to have a regional rather than universal distribution. Many of these various cytochromes P450 have been shown to catalyze the metabolism of neurosteroids as well as other biologically significant compounds in brain. In addition, many cytochrome P450 enzymes have been implicated in the metabolism of psychoactive drugs such as neuroleptics and antidepressants. The regulation of cytochrome: P450 expression has been studied at greater detail, the regulation of aromatase being a prominent example during the last five years.

引用

页码：199 / 214

页数：16

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