Biomarkers in Acute Lung Injury-Marking Forward Progress

被引：90

作者：

Barnett, Nicolas ^{[1
]}

Ware, Lorraine B. ^{[1
]}

机构：

[1] Vanderbilt Univ, Div Allergy Pulm & Crit Care Med, Dept Med, Nashville, TN 37232 USA

来源：

CRITICAL CARE CLINICS | 2011年 / 27卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Biomarkers; Clinical predictors; ALI; ARDS; RESPIRATORY-DISTRESS-SYNDROME; PULMONARY-EDEMA FLUID; VON-WILLEBRAND-FACTOR; LIPOPOLYSACCHARIDE-BINDING PROTEIN; INTERCELLULAR-ADHESION MOLECULE-1; GLYCATION END-PRODUCTS; SOLUBLE E-SELECTIN; CLINICAL-OUTCOMES; FACTOR ANTIGEN; PLASMA-LEVELS;

D O I：

10.1016/j.ccc.2011.04.001

中图分类号：

R4 [临床医学];

学科分类号：

100218 [急诊医学];

摘要：

This article reviews the state of the art regarding biomarkers for prediction, diagnosis, and prognosis in acute lung injury. Biomarkers and the goals of biomarker research are defined. Progress along 4 general routes is examined. First, the results of wide-ranging existing protein biomarkers are reported. Second, newer biomarkers awaiting or with strong potential for validation are described. Third, progress in the fields of genomics and proteomics is reported. Finally, given the complexity and number of potential biomarkers, the results of combining clinical predictors with protein and other biomarkers to produce better prognostic and diagnostic indices are examined.

引用

页码：661 / +

页数：24

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