Solid-state NMR in drug design and discovery for membrane-embedded targets

被引:91
作者
Watts, A [1 ]
机构
[1] Univ Oxford, Dept Biochem, Biomembrane Struct Unit, Oxford OX1 3QU, England
[2] Rutherford Appleton Labs, Biol Solid State NMR Facil, Chilton OX10 0QX, England
基金
英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会; 英国医学研究理事会;
关键词
D O I
10.1038/nrd1773
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Observing drugs and ligands at their site of action in membrane proteins is now possible through the use of a development in biomolecular NMR spectroscopy known as solid-state NMR. Even large, functionally active complexes are being examined using this method, with structural details being resolved at super-high subnanometre resolution. This is supplemented by detailed dynamic and electronic information about the surrounding ligand environment, and gives surprising new insights into the way in which ligands bind, which can aid drug design.
引用
收藏
页码:555 / 568
页数:14
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