Epigenetic inheritance of cell differentiation status

被引：114

作者：

Ng, Ray K. ^{[2
]}

Gurdon, John B. ^{[1
,3
]}

机构：

[1] Canc Res UK Gurdon Inst, Wellcome Trust, Cambridge CB2 1QN, England

[2] Babraham Inst, Lab Dev Genet & Imprinting, Cambridge, England

[3] Univ Cambridge, Dept Zool, Cambridge, England

来源：

CELL CYCLE | 2008年 / 7卷 / 09期

基金：

英国医学研究理事会; 英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

nuclear transplantation; epigenetic memory; cell differentiation; inheritance; DNA methylation; histone variant;

D O I：

10.4161/cc.7.9.5791

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Epigenetic modifications influence gene expression pattern and provide a unique signature of a cell differentiation status. Without external stimuli or signalling events, this cell identity remains stable and unlikely to change over many cell divisions. The epigenetic signature of a particular cell fate therefore needs to be replicated faithfully in daughter cells; otherwise a cell lineage cannot be maintained. However, the mechanism of transmission of cellular memory from mother to daughter cells remains unclear. It has been suggested that the inheritance of an active or silent gene state involves different kinds of epigenetic mechanisms, e. g., DNA methylation, histone modifications, replacement of histone variants, Polycomb group (PcG) and Trithorax group (TrxG) proteins. Emerging evidence supports the role of histone variant H3.3 in maintaining an active gene status and in remodelling nucleosomal composition. Here we discuss some recent findings on the propagation of epigenetic memory and propose a model for the inheritance of an active gene state through the interaction of H3.3 with other epigenetic components.

引用

页码：1173 / 1177

页数：5

共 38 条

[1] DNA methylation patterns and epigenetic memory [J].

Bird, A .

GENES & DEVELOPMENT, 2002, 16 (01) :6-21

[2] Methylation-induced repression - Belts, braces, and chromatin [J].

Bird, AP ;

Wolffe, AP .

CELL, 1999, 99 (05) :451-454

[3] Oct4 distribution and level in mouse clones:: consequences for pluripotency [J].

Boiani, M ;

Eckardt, S ;

Schöler, HR ;

McLaughlin, KJ .

GENES & DEVELOPMENT, 2002, 16 (10) :1209-1219

[4] Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei [J].

Bortvin, A ;

Eggan, K ;

Skaletsky, H ;

Akutsu, H ;

Berry, DL ;

Yanagimachi, R ;

Page, DC ;

Jaenisch, R .

DEVELOPMENT, 2003, 130 (08) :1673-1680

[5] Variant histone H3.3 marks promoters of transcriptionally active genes during mammalian cell division [J].

Chow, CM ;

Georgiou, A ;

Szutorisz, H ;

Silva, AME ;

Pombo, A ;

Barahona, I ;

Dargelos, E ;

Canzonetta, C ;

Dillon, N .

EMBO REPORTS, 2005, 6 (04) :354-360

[6] Conservation of methylation reprogramming in mammalian development: Aberrant reprogramming in cloned embryos [J].

Dean, W ;

Santos, F ;

Stojkovic, M ;

Zakhartchenko, V ;

Walter, J ;

Wolf, E ;

Reik, W .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (24) :13734-13738

[7] DNA methylation supports intrinsic epigenetic memory in mammalian cells [J].

Feng, Yong-Qing ;

Desprat, Romain ;

Fu, Haiqing ;

Olivier, Emmanuel ;

Lin, Chii Mei ;

Lobell, Amanda ;

Gowda, Shilpa N. ;

Aladjem, Mirit I. ;

Bouhassira, Eric E. .

PLOS GENETICS, 2006, 2 (04) :461-470

[8] DNA methylation in insects [J].

Field, LM ;

Lyko, F ;

Mandrioli, M ;

Prantera, G .

INSECT MOLECULAR BIOLOGY, 2004, 13 (02) :109-115

[9] The first half-century of nuclear transplantation [J].

Gurdon, JB ;

Byrne, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (14) :8048-8052

[10] Histone H3 variants and their potential role in indexing mammalian genomes: The "H3 barcode hypothesis" [J].

Hake, SB ;

Allis, CD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (17) :6428-6435

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