Tanshinone IIA from Salvia miltiorrhiza inhibits inducible nitric oxide synthase expression and production of TNF-α, IL-1β and IL-6 in activated RAW 264.7 cells

被引：65

作者：

Jang, SI

Jeong, SI

Kim, KJ

Kim, HJ

Yu, HH

Park, R

Kim, HM

You, YO

机构：

[1] Wonkwang Univ, Sch Dent, Dept Oral Biochem, Iksan 570749, Chonbuk, South Korea

[2] Wonkwang Univ, Sch Dent, Dept Oral Biol, Iksan, South Korea

[3] Wonkwang Univ, Sch Dent, VCRC, Iksan, South Korea

[4] Wonkwang Univ, Sch Med, Dept Microbiol, Iksan, South Korea

[5] Wonkwang Univ, Sch Med, VCRC, Iksan, South Korea

[6] Kyung Hee Univ, Coll Oriental Med, Dept Pharmacol, Seoul, South Korea

来源：

PLANTA MEDICA | 2003年 / 69卷 / 11期

关键词：

D O I：

暂无

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

The inhibitory effects of tanshinone IIA, a diterpene isolated from Salvia miltiorrhiza root, on the production of nitric oxide (NO), interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), and the expression of inducible nitric oxide synthase (iNOS) were investigated in activated RAW 264.7 cells. This compound markedly inhibited the production of NO, IL-1beta and TNF-alpha, and suppressed the expression of iNOS in a close-dependent manner. These results suggest that the traditional use of S. miltiorrhiza as an anti-inflammatory herbal medicine may be explained, in part, by the inhibition of NO, IL-1beta, IL-6 and TNF-alpha production, and expression of iNOS.

引用

页码：1057 / 1059

页数：3

共 9 条

[1]

Double-stranded RNA-induced inducible nitric-oxide synthase expression and interleukin-1 release by murine macrophages requires NF-κB activation [J].