Metalloproteinases and their inhibitors: Regulators of wound healing

被引：541

作者：

Gill, Sean E. ^{[1
]}

Parks, William C. ^{[1
]}

机构：

[1] Univ Washington, Ctr Lung Biol, Seattle, WA 98109 USA

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2008年 / 40卷 / 6-7期

关键词：

wound healing; inflammation; metalloproteinases; chemokines; extracellular matrix;

D O I：

10.1016/j.biocel.2007.10.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Wound healing is a dynamic process that involves a coordinated response of many cell types representing distinct tissue compartments and is fundamentally similar among tissue types. Among the many gene products that are essential for restoration of normal tissue architecture, several members of the matrix metalloproteinase (MMP) family function as positive and, at times, negative regulators of repair processes. MMPs were initially thought to only function in the resolution phase of wound healing, particularly during scar resorption; however, recent evidence suggests that they also influence other wound-healing responses, such as inflarnmation and re-epithelialization. In this review, we discuss what is currently known about the function of MMPs in wound healing and will provide suggestions for future research directions. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：1334 / 1347

页数：14

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