The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-κB that blocks TNFα-induced apoptosis

Bcl-2-family proteins are key regulators of the apoptotic response. Here, we demonstrate that the pro-survival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappa B. We show that bfl-1 gene expression is dependent on NF-kappa B activity and that it can substitute for NF-kappa B to suppress TNF alpha-induced apoptosis. bfl-1 promoter analysis identified an NE-KB site responsible for its Rel/NF-kappa B-dependent induction. The expression of bfl-1 in immune tissues supports the protective role of NF-kappa B in the immune system. The activation of Bfl-1 may be the means by which NF-KB functions in oncogenesis and promotes cell resistance to anti-cancer therapy.