Integrins: roles in cancer development and as treatment targets

被引：443

作者：

Jin, H

Varner, J

机构：

[1] Univ Calif San Diego, Dept Med, John & Rebecca Moores Comprehens Canc Ctr, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

来源：

BRITISH JOURNAL OF CANCER | 2004年 / 90卷 / 03期

关键词：

angiogenesis; metastasis; apoptosis; integrin alpha 5 beta 1; integrin alpha v beta 3;

D O I：

10.1038/sj.bjc.6601576

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The integrin family of cell adhesion proteins promotes the attachment and migration of cells on the surrounding extracellular matrix (ECM). Through signals transduced upon integrin ligation by ECM proteins or immunoglobulin superfamily molecules, this family of proteins plays key roles in regulating tumour growth and metastasis as well as tumour angiogenesis. Several integrins play key roles in promoting tumour angiogenesis and tumour metastasis. Antagonists of several integrins (alpha5beta1, alphavbeta3 and alphavbeta5) are now under evaluation in clinical trials to determine their potential as therapeutics for cancer and other diseases.

引用

收藏

页码：561 / 565

页数：5

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