Scaffolds for microtubule inhibition through extensive modification of the epothilone template

被引：36

作者：

Cachoux, F

Isarno, T

Wartmann, M

Altmann, KH

机构：

[1] ETH Honggerberg, Inst Pharmaceut Sci, Dept Chem & Appl Biosci, CH-8093 Zurich, Switzerland

[2] Novartis Inst Biomed Res, Basel, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 45期

关键词：

antitumor agents; drug design; epothilones; microtubule stabilizers; natural products; total synthesis;

D O I：

10.1002/anie.200501760

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

(Chemical Equation Presented) The microtubule-stabilizing agent 1 was obtained through extensive modification (colored circles) of the structure of natural epothilone. Despite these structural differences, the biological potency of 1 is comparable with that of epothilone A and taxol! © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7469 / 7473

页数：5

共 36 条

[1]

Recent developments in the chemical biology of epothilones [J].