Impulsive and Compulsive Behaviors in Parkinson's Disease

被引：177

作者：

Evans, Andrew H. ^{[1
,2
]}

Strafella, Antonio P. ^{[3
]}

Weintraub, Daniel ^{[4
]}

Stacy, Mark ^{[5
]}

机构：

[1] Royal Melbourne Hosp, Dept Neurol, Movement Disorders Serv, Parkville, Vic 3050, Australia

[2] Univ Melbourne, Dept Med, Parkville, Vic 3052, Australia

[3] Univ Toronto, Toronto Western Hosp, Movement Disorders Ctr, UHN & PET Imaging Ctr,Ctr Addict & Mental Hlth, Toronto, ON M5S 1A1, Canada

[4] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA

[5] Duke Univ, Med Ctr, Durham, NC USA

来源：

MOVEMENT DISORDERS | 2009年 / 24卷 / 11期

关键词：

Parkinson's disease; impulse control disorders; dopamine dysregulation syndrome; punding; mesolimbic; reward; ventral striatum; DOPAMINE AGONIST THERAPY; HEDONISTIC HOMEOSTATIC DYSREGULATION; REWARD-SEEKING BEHAVIOR; SUBTHALAMIC NUCLEUS; CONTROL DISORDERS; REACTION-TIME; REPETITIVE BEHAVIORS; REPLACEMENT THERAPY; CLINICAL-FEATURES; DRUG-ADDICTION;

D O I：

10.1002/mds.22505

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Antiparkinson therapy can be the primary cause of it range of nonmotor symptoms that include it set of complex disinhibitory psychomotor pathologies and are linked by their repetitive. reward or incentive-based natures. These behaviors relate to aberrant or excessive dopamine receptor stimulation and encompass impulse control disorders (ICDs), punding, and the dopamine clysregulation syndrome (DIDS). Common ICDs include pathological gambling, hypersexuality, compulsive eating, Bind Compulsive buying. This review focuses on the phenomenology, epidemiology, and methods to identify and rate these disorders. The management of dopaminergic drug-related Compulsive behaviors is discussed in the light of the current understanding of the neurobiological substrate of these disorders. (C) 2009 Movement Disorder Society

引用

页码：1561 / 1570

页数：10

共 127 条

[1]

Behavioral changes associated with deep brain stimulation surgery for Parkinson’s disease [J].