Upper airway . 1: Allergic rhinitis and asthma: united disease through epithelial cells

被引：88

作者：

Bourdin, A. ^{[3
]}

Gras, D. ^{[2
]}

Vachier, I. ^{[3
]}

Chanez, P. ^{[1
,2
]}

机构：

[1] Univ Mediterranee, AP HM, Serv Pneumoallergol, F-13009 Marseille, France

[2] Univ Mediterranee, Immunol Lab, INSERM, U600, F-13009 Marseille, France

[3] CHU Arnaud Villeneuve, Dept Resp Dis, Montpellier, France

来源：

THORAX | 2009年 / 64卷 / 11期

关键词：

EPIDERMAL-GROWTH-FACTOR; INDEPENDENT RISK-FACTOR; FACTOR RECEPTOR; NASAL-MUCOSA; BRONCHIAL EPITHELIUM; SIGNAL TRANSDUCER; CHRONIC SINUSITIS; MUCIN EXPRESSION; MAST-CELL; INFLAMMATION;

D O I：

10.1136/thx.2008.112862

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

100201 [内科学];

摘要：

The relationship between allergic rhinitis and asthma is now established, and most of the clinical, epidemiological and biological data recommend integrated management. Epithelial cells represent the first barrier of the upper and lower respiratory tracts and thus are logical targets for a comprehensive integrated therapeutic approach. This review discusses rhinosinusitis as a co-morbid condition, a precipitating or triggering condition, and an epiphenomenon as an integrated part of the disease. A better understanding and a more pragmatic method of diagnosis and management is needed using cost-effective long-term strategies.

引用

页码：999 / 1004

页数：6

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