Novel functions of interferon-induced proteins

被引：50

作者：

Sen, GC ^{[1
]}

机构：

[1] Cleveland Clin Fdn, Lerner Res Inst, Dept Mol Biol NC20, Cleveland, OH 44195 USA

来源：

SEMINARS IN CANCER BIOLOGY | 2000年 / 10卷 / 02期

基金：

美国国家卫生研究院;

关键词：

IFN-induced proteins; P56; PKR; P200; 2-5(A) synthetase;

D O I：

10.1006/scbi.2000.0312

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Interferons are important cytokines which regulate antiviral, cell growth, immune modulatory and anti-tumor functions. These pleiotropic effects of interferons are brought about by a large number of cellular proteins, the interferon-inducible proteins. Investigation of the biochemical and cellular activities of some of these proteins have revealed new pathways of regulation of cellular RNA and protein metabolism, growth and differentiation, apoptosis and signal transduction. In this article we discuss recent findings on the novel activities of a selected number of interferon-induced proteins.

引用

页码：93 / 101

页数：9

共 45 条

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