Mechanical signals, IGF-I gene splicing, and muscle adaptation

被引：135

作者：

Goldspink, G ^{[1
]}

机构：

[1] UCL Royal Free & Univ Coll, Sch Med, Basic Div Basic Med Sci, London, England

[2] UCL Royal Free & Univ Coll, Sch Med, Dept Surg, London, England

来源：

PHYSIOLOGY | 2005年 / 20卷

基金：

英国惠康基金;

关键词：

D O I：

10.1152/physiol.00004.2005

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Combining physiological and molecular biology methods made it possible to identify and characterize a local muscle growth/repair factor (MGF). Following resistance exercise, MGF "kick starts" muscle hypertrophy and is important in local tissue repair. Loss of muscle mass in old age and certain diseases is associated with an impaired ability to express MGF.

引用

页码：232 / 238

页数：7

共 31 条

[1] Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function [J].

Barton-Davis, ER ;

Shoturma, DI ;

Musaro, A ;

Rosenthal, N ;

Sweeney, HL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (26) :15603-15607

[2] Net fluxes over working thigh of hormones, growth factors and biomarkers of bone metabolism during short lasting dynamic exercise [J].

Brahm, H ;

PiehlAulin, K ;

Saltin, B ;

Ljunghall, S .

CALCIFIED TISSUE INTERNATIONAL, 1997, 60 (02) :175-180

[3] Severity of contraction-induced injury is affected by velocity only during stretches of large strain [J].

Brooks, SV ;

Faulkner, JA .

JOURNAL OF APPLIED PHYSIOLOGY, 2001, 91 (02) :661-666

[4] THE MUSCLE SATELLITE CELL - A REVIEW [J].

CAMPION, DR .

INTERNATIONAL REVIEW OF CYTOLOGY-A SURVEY OF CELL BIOLOGY, 1984, 87 :225-251

[5]

Cohn RD, 2000, MUSCLE NERVE, V23, P1456, DOI 10.1002/1097-4598(200010)23:10<1456::AID-MUS2>3.0.CO

[6]

2-T

[7] MYOGENIC VECTOR EXPRESSION OF INSULIN-LIKE GROWTH-FACTOR-I STIMULATES MUSCLE-CELL DIFFERENTIATION AND MYOFIBER HYPERTROPHY IN TRANSGENIC MICE [J].

COLEMAN, ME ;

DEMAYO, F ;

YIN, KC ;

LEE, HM ;

GESKE, R ;

MONTGOMERY, C ;

SCHWARTZ, RJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (20) :12109-12116

[8] MODULATION OF IGF MESSENGER-RNA ABUNDANCE DURING STRETCH-INDUCED SKELETAL-MUSCLE HYPERTROPHY AND REGRESSION [J].

CZERWINSKI, SM ;

MARTIN, JM ;

BECHTEL, PJ .

JOURNAL OF APPLIED PHYSIOLOGY, 1994, 76 (05) :2026-2030

[9] Skeletal muscle repair by adult human mesenchymal stem cells from synovial membrane [J].

De Bari, C ;

Dell'Accio, F ;

Vandenabeele, F ;

Vermeesch, JR ;

Raymackcrs, JM ;

Luyten, FP .

JOURNAL OF CELL BIOLOGY, 2003, 160 (06) :909-918

[10]

GOLDSPINK G, 1992, AM J PHYSIOL, V262, pR326

← 1 2 3 4 →