Synthesis and anticancer activity of novel chiral D-glucose derived bis-imidazoles and their analogs

被引：36

作者：

Zhou, CH ^{[1
]}

Hassner, A ^{[1
]}

机构：

[1] Bar Ilan Univ, Dept Chem, IL-52900 Ramat Gan, Israel

来源：

CARBOHYDRATE RESEARCH | 2001年 / 333卷 / 04期

关键词：

carbohydrates; glucosides; imidazoles; organic synthesis; biological activity; H-1 and C-13 NMR;

D O I：

10.1016/S0008-6215(01)00154-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

A series of novel D-glucose derived bis-imidazoles and their analogs, which possess potential in bioorganic and supramolecular chemistry, were designed and synthesized from methyl alpha -D-glucoside through protection, bis-bromination, N-alkylation and deprotection. All new compounds were characterized by HRMS, H-1, C-13 and DEFT NMR spectroscopy as well as elemental analysis. The H-1-H-1 and H-1-C-13 2D NMR spectra for some compounds were also recorded. Some regular features of C-13 and H-1 NMR spectra were summarized. The anticancer activity of some compounds was evaluated. (C) 2001 Published by Elsevier Science Ltd.

引用

页码：313 / 326

页数：14

共 36 条

[1]

Heterocyclic betaines. 30. A direct synthetic approach to novel quadrupolar [1(4)]azolophanes [J].