Functional consequences of integrin gene mutations in mice

被引：174

作者：

Bouvard, D ^{[1
]}

Brakebusch, C ^{[1
]}

Gustafsson, E ^{[1
]}

Aszódi, A ^{[1
]}

Bengtsson, T ^{[1
]}

Berna, A ^{[1
]}

Fässler, R ^{[1
]}

机构：

[1] Lund Univ, Dept Expt Pathol, Lund, Sweden

来源：

CIRCULATION RESEARCH | 2001年 / 89卷 / 03期

关键词：

integrin; knockout; extracellular matrix;

D O I：

10.1161/hh1501.094874

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Integrins are cell-surface receptors responsible for cell attachment to extracellular matrices and to other cells. The application of mouse genetics has significantly increased our understanding of integrin function in vivo. In this review, we summarize the phenotypes of mice carrying mutant integrin genes and compare them with phenotypes of mice lacking the integrin ligands.

引用

页码：211 / 223

页数：13

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