Achaete-scute homolog-1 and development Notch in lung neuroendocrine and cancer

被引：98

作者：

Ball, DW ^{[1
]}

机构：

[1] Johns Hopkins Med Inst, Sidney Kimmel Comprehens Canc Ctr, Dept Med, Baltimore, MD 21231 USA

来源：

CANCER LETTERS | 2004年 / 204卷 / 02期

关键词：

hASH1; mammalian achaete-scute homolog-1; Notch; hairy-enhancer of split 1; neuroendocrine; lung development; lung cancer;

D O I：

10.1016/S0304-3835(03)00452-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Achaete-scute homolog-1 (termed Mash1 in rodents, hASH1 in humans) is a basic helix-loop-helix transcription factor important in early development of neural and neuroendocrine (NE) progenitor cells in multiple tissues including the CNS, autonomic nervous system, adrenal medulla, thyroid, lung, and prostate, among others. This review discusses how progress in developmental neurobiology of Mash1 has translated into novel insights in NE tumor biology, particularly for small cell lung cancer. Inhibition of this factor by the Notch pathway is essential in regulating NE commitment in airway epithelial precursor cells. and may play a comparable role in modulating phenotypes of lung cancer and other tumors. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：159 / 169

页数：11

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