Distinct recognition of non-clade B human immunodeficiency virus type 1 epitopes by cytotoxic T lymphocytes generated from donors infected in Africa

被引：63

作者：

Dorrell, L

Dong, T

Ogg, GS

Lister, S

McAdam, S

Rostron, T

Conlon, C

McMichael, AJ

Rowland-Jones, SL ^{[1
]}

机构：

[1] John Radcliffe Hosp, Inst Mol Med, Mol Immunol Grp, Oxford OX3 9DS, England

[2] Imperial Coll Sch Med, Dept Genitourinary Med, London W2 1PG, England

[3] John Radcliffe Hosp, Nuffield Dept Med, Oxford OX3 9DU, England

来源：

JOURNAL OF VIROLOGY | 1999年 / 73卷 / 02期

关键词：

D O I：

10.1128/JVI.73.2.1708-1714.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We present detailed studies of human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte (CTE) responses to clade A or C HIV type 1 in three donors infected in East Africa. We define several novel non-clade B CTL epitopes, including some restricted by HLA alleles common in Africans. Although cross-clade CTL recognition of these epitopes does occur, recognition can also be highly clade specific.

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页码：1708 / 1714

页数：7

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