Distinct recognition of non-clade B human immunodeficiency virus type 1 epitopes by cytotoxic T lymphocytes generated from donors infected in Africa

被引:63
作者
Dorrell, L
Dong, T
Ogg, GS
Lister, S
McAdam, S
Rostron, T
Conlon, C
McMichael, AJ
Rowland-Jones, SL [1 ]
机构
[1] John Radcliffe Hosp, Inst Mol Med, Mol Immunol Grp, Oxford OX3 9DS, England
[2] Imperial Coll Sch Med, Dept Genitourinary Med, London W2 1PG, England
[3] John Radcliffe Hosp, Nuffield Dept Med, Oxford OX3 9DU, England
关键词
D O I
10.1128/JVI.73.2.1708-1714.1999
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
We present detailed studies of human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte (CTE) responses to clade A or C HIV type 1 in three donors infected in East Africa. We define several novel non-clade B CTL epitopes, including some restricted by HLA alleles common in Africans. Although cross-clade CTL recognition of these epitopes does occur, recognition can also be highly clade specific.
引用
收藏
页码:1708 / 1714
页数:7
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