Stereoselective synthesis of anti-β-hydroxy-α-amino acids through dynamic kinetic resolution

被引：112

作者：

Makino, K ^{[1
]}

Goto, T ^{[1
]}

Hiroki, Y ^{[1
]}

Hamada, Y ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Inage Ku, Chiba 2638522, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 07期

关键词：

amino acids; asymmetric synthesis; hydrogenation; kinetic resolution; ruthenium;

D O I：

10.1002/anie.200353072

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Upping the anti: Asymmetric anti-selective hydrogenation of α-amino-β-keto esters through dynamic kinetic resolution has been achieved for the first time by using the Ru-binap catalyst. The reaction affords important anti-β-hydroxy-α-amino acids with 74-98% ee and high diastereomeric ratio in excellent yields (see scheme; binap = 2,2′-bis(diphenylphosphanyl)-1,1′-binaphthyl).

引用

页码：882 / 884

页数：3

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