The sFlt-1/PlGF ratio in different types of hypertensive pregnancy disorders and its prognostic potential in preeclamptic patients

被引：354

作者：

Verlohren, Stefan ^{[1
]}

Herraiz, Ignacio ^{[5
]}

Lapaire, Olav ^{[6
]}

Schlembach, Dietmar ^{[7
]}

Moertl, Manfred ^{[7
]}

Zeisler, Harald ^{[8
]}

Calda, Pavel ^{[9
]}

Holzgreve, Wolfgang ^{[2
]}

Galindo, Alberto ^{[5
]}

Engels, Theresa ^{[1
]}

Denk, Barbara ^{[3
]}

Stepan, Holger ^{[4
]}

机构：

[1] Charite, Dept Obstet, Campus Virchow Clin, D-13353 Berlin, Germany

[2] Inst Adv Study, Berlin, Germany

[3] Roche Diagnost, Clin Operat Profess Diagnost, Penzberg, Germany

[4] Univ Hosp Leipzig, Dept Obstet, Leipzig, Germany

[5] Univ Hosp 12 Octubre, Dept Obstet & Gynecol, Madrid, Spain

[6] Univ Basel, Dept Obstet & Gynecol, Basel, Switzerland

[7] Med Univ Graz, Dept Obstet & Gynecol, Graz, Austria

[8] Univ Vienna, Sch Med, Dept Obstet & Gynecol, Vienna, Austria

[9] Charles Univ Prague, Dept Obstet & Gynecol, Prague, Czech Republic

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2012年 / 206卷 / 01期

关键词：

gestational hypertension; placental growth factor; PIGF; preeclampsia; singleton pregnancy; soluble fms-like tyrosine kinase; sFlt-1; CIRCULATING ANTIANGIOGENIC FACTORS; PLACENTAL GROWTH-FACTOR; ANGIOGENIC FACTORS; MATERNAL PLASMA; GESTATIONAL HYPERTENSION; SOLUBLE ENDOGLIN; DELIVERY; MANAGEMENT; MORTALITY; CAROLINA;

D O I：

10.1016/j.ajog.2011.07.037

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: The soluble fms-like tyrosine kinase (sFlt-1)/placental growth factor (PlGF) ratio is a reliable tool in the assessment of preeclampsia. We tested the hypothesis that the sFlt-1/PlGF ratio is able to identify women at risk for imminent delivery. We characterized the sFlt1/PlGF ratio in different types of hypertensive pregnancy disorders. STUDY DESIGN: We investigated 388 singleton pregnancies with normal pregnancy outcome, 164 with PE, 36 with gestational hypertension, and 42 with chronic hypertension. sFlt-1 and PlGF were measured in serum samples. RESULTS: Patients with preeclampsia had a significantly increased sFlt-1/PlGF ratio as compared with controls and with patients with chronic and gestational hypertension in < 34 weeks and >= 34 weeks (P <.001). Time to delivery was significantly reduced in women with preeclampsia in the highest quartile of the sFlt-1/PlGF ratio (P <.001). CONCLUSION: The sFlt-1/PlGF ratio allows the identification of women at risk for imminent delivery and is a reliable tool to discriminate between different types of pregnancy-related hypertensive disorders.

引用

页码：58.e1 / 58.e8

页数：8

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