HIV-1 accessory proteins - Ensuring viral survival in a hostile environment

被引：456

作者：

Malim, Michael H. ^{[1
]}

Emerman, Michael ^{[2
]}

机构：

[1] Kings Coll London, Guys Hosp, Dept Infect Dis, Sch Med,Borough Wing, London SE1 9RT, England

[2] Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98109 USA

来源：

CELL HOST & MICROBE | 2008年 / 3卷 / 06期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.chom.2008.04.008

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

One of the features of primate immunodeficiency viruses (HIVs and SIVs) that distinguishes them from other retroviruses is the array of "accessory" proteins they encode. Here, we discuss recent advances in understanding the interactions of the HIV-1 Nef, Vif, Vpu, and Vpr proteins with factors and pathways expressed in cells of the immune system. In at least three instances, the principal activity of the accessory proteins appears to be evasion from various forms of cell-mediated (or intrinsic), antiviral resistance. Broadly speaking, the HIV-1 accessory proteins modify the local environment within infected cells to ensure viral persistence, replication, dissemination, and transmission.

引用

页码：388 / 398

页数：11

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