The Role of Inflammation and Infection in Preterm Birth

被引：111

作者：

Bastek, Jamie A. ^{[1
,2
,3
]}

Gomez, Luis M. ^{[1
,2
,3
]}

Elovitz, Michal A. ^{[1
,2
,3
]}

机构：

[1] Hosp Univ Penn, Dept Maternal Fetal Med, Philadelphia, PA 19104 USA

[2] Maternal & Child Hlth Res Program, Philadelphia, PA USA

[3] Univ Penn, Dept Obstet & Gynecol, Ctr Res Reprod & Womens Hlth, Philadelphia, PA 19104 USA

来源：

CLINICS IN PERINATOLOGY | 2011年 / 38卷 / 03期

关键词：

Preterm birth; Inflammation; Infection; Animal model; Biomarkers; TUMOR-NECROSIS-FACTOR; AMNIOTIC-FLUID INTERLEUKIN-6; NF-KAPPA-B; POLYMERASE-CHAIN-REACTION; ACTIVATING PEPTIDE-1 INTERLEUKIN-8; TOLL-LIKE RECEPTORS; FACTOR-ALPHA; INTRAUTERINE INFECTION; FETAL FIBRONECTIN; HISTOLOGIC CHORIOAMNIONITIS;

D O I：

10.1016/j.clp.2011.06.003

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Much emphasis in recent decades has been devoted to inflammation and infection as a premier causal mechanism of preterm birth. This article explores the epidemiologic, clinical, and animal data that exist to support this conceptual paradigm as well as proposed mechanisms through which to potentially mitigate the adversity of prematurity. Truly successful interventions are not likely to occur until the pathogenesis of preterm birth and the role of inflammation in causing not only parturition but also fetal and neonatal injury is fully elucidated.

引用

页码：385 / +

页数：24

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