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Cardiovascular genomics: Estimating the total number of genes expressed in the human cardiovascular system

被引：26
作者：
Dempsey, AA
Dzau, VJ
Liew, CC
机构：
[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Cardiovasc Genome Unit, Boston, MA 02115 USA
[2] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5G 1L5, Canada
来源：
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 2001年 / 33卷 / 10期
关键词：
gene expression; genomics; human genome; cardiovascular genome;
D O I：
10.1006/jmcc.2001.1447
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The number of genes encoded by the human genome has long sought to be determined. With the recent publications of the complete sequence of the human genome, the number of genes encoded by the human genome has now been estimated to be similar to 32 000-38 000. Now the next step will be to determine which of these genes arc expressed in a given cell. tissue or organ. Using three unique approaches taking advantage of our current cardiovascular EST database and the complete nucleotide sequence of human chromosomes 21 and 22 as welt as cDNA microarray hybridization, we estimate that between 20 930-27 160 genes are expressed in the cardiovascular system. (C) 2001 Academic Press.
引用
收藏
页码：1879 / 1886
页数：8
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