Successful treatment of non-familial haemophagocytic lymphohistiocytosis with interferon and gammaglobulin

被引：10

作者：

Estlin, EJ ^{[1
]}

Palmer, RD ^{[1
]}

Windebank, KP ^{[1
]}

Lowry, MF ^{[1
]}

Pearson, ADJ ^{[1
]}

机构：

[1] SUNDERLAND DIST GEN HOSP,SUNDERLAND SR4 7TP,DURHAM,ENGLAND

来源：

ARCHIVES OF DISEASE IN CHILDHOOD | 1996年 / 75卷 / 05期

关键词：

haemophagocytic lymphohistiocytosis; interfornalfa; intravenous gammaglobulin;

D O I：

10.1136/adc.75.5.432

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Two cases of non-familial haemophagocytic lymphohistiocytosis (HLH) are presented in which treatment with interferon alfa and gammaglobulin was associated with complete clinical remission. In one case, serological evidence of recent Epstein-Barr virus infection was found. Natural killer cell activity was within normal limits in both children, compatible with a secondary form of HLH. The combination of interferon alfa and intravenous gammaglobulin requires further evaluation in the treatment of nonfamilial HLH.

引用

页码：432 / 435

页数：4

共 18 条

[1]

BOLME P, 1995, BONE MARROW TRANSPL, V15, P331

[2] BIOLOGICAL BASIS FOR THE CLINICAL USE OF INTERFERON [J].

DIANZANI, F .

GUT, 1993, 34 (02) :S74-S76

[3] NATURAL-KILLER CELL-FUNCTION AND INTERFERON-PRODUCTION IN FAMILIAL HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS [J].

EIFE, R ;

JANKA, GE ;

BELOHRADSKY, BH ;

HOLTMANN, H .

PEDIATRIC HEMATOLOGY AND ONCOLOGY, 1989, 6 (03) :265-272

[4] INTRAVENOUS IMMUNOGLOBULIN IN VIRUS ASSOCIATED HEMOPHAGOCYTIC SYNDROME [J].

GOULDER, P ;

SEWARD, D ;

HATTON, C .

ARCHIVES OF DISEASE IN CHILDHOOD, 1990, 65 (11) :1275-1277

[5] EPIPODOPHYLLOTOXINS, ALKYLATING-AGENTS, AND RADIATION AND RISK OF SECONDARY LEUKEMIA AFTER CHILDHOOD-CANCER [J].

HAWKINS, MM ;

WILSON, LMK ;

STOVALL, MA ;

MARSDEN, HB ;

POTOK, MHN ;

KINGSTON, JE ;

CHESSELLS, JM .

BRITISH MEDICAL JOURNAL, 1992, 304 (6832) :951-958

[6] HYPERCYTOKINEMIA IN FAMILIAL HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS [J].

HENTER, JI ;

ELINDER, G ;

SODER, O ;

HANSSON, M ;

ANDERSSON, B ;

ANDERSSON, U .

BLOOD, 1991, 78 (11) :2918-2922

[7] HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS - EXPERIENCE AT 2 UK CENTERS [J].

HIRST, WJR ;

LAYTON, DM ;

SINGH, S ;

MIELIVERGANI, G ;

CHESSELLS, JM ;

STROBEL, S ;

PRITCHARD, J .

BRITISH JOURNAL OF HAEMATOLOGY, 1994, 88 (04) :731-739

[8] HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS, INTERFERON-GAMMA-NAEMIA AND EPSTEIN-BARR-VIRUS INVOLVEMENT [J].

IMASHUKU, S ;

HIBI, S ;

FUJIWARA, F ;

IKUSHIMA, S ;

TODO, S .

BRITISH JOURNAL OF HAEMATOLOGY, 1994, 88 (03) :656-658

[9] SOLUBLE INTERLEUKIN-2 RECEPTOR IN HEMOPHAGOCYTIC HISTIOCYTOSES - SEARCHING FOR MARKERS OF DISEASE-ACTIVITY [J].

KOMP, DM ;

BUCKLEY, PJ ;

MCNAMARA, J ;

VANHOFF, J .

PEDIATRIC HEMATOLOGY AND ONCOLOGY, 1989, 6 (03) :253-264

[10]

LAUER SJ, 1994, CANCER-AM CANCER SOC, V74, P197, DOI 10.1002/1097-0142(19940701)74:1<197::AID-CNCR2820740131>3.0.CO

← 1 2 →