Synthesis and antibacterial activity of [6,5,5] and [6,6,5] tricyclic fused oxazolidinones

被引：34

作者：

Gleave, DM ^{[1
]}

Brickner, SJ

Manninen, PR

Allwine, DA

Lovasz, KD

Rohrer, DC

Tucker, JA

Zurenko, GE

Ford, CW

机构：

[1] Pharmacia & Upjohn Inc, Med Chem Res, Kalamazoo, MI 49001 USA

[2] Pharmacia & Upjohn Inc, Comp Aided Drug Discovery, Kalamazoo, MI 49001 USA

[3] Pharmacia & Upjohn Inc, Canc & Infect Dis Res, Kalamazoo, MI 49001 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(98)00194-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of conformationally restricted, [6,5,5] and [6,6,5] tricyclic fused oxazolidinones were synthesized and tested for antibacterial activity. Several compounds in the trans-[6,5,5] series demonstrated potent in vitro and in vivo activity. This work provides valuable information regarding the preferred conformational orientation of the oxazolidinones site. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1231 / 1236

页数：6

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