Kinetic evidence for a tetrameric transition state in the asymmetric autocatalytic alkylation of pyrimidyl aldehydes

被引：81

作者：

Buono, FG ^{[1
]}

Blackmond, DG ^{[1
]}

机构：

[1] Univ Hull, Dept Chem, Kingston Upon Hull HU6 7RX, N Humberside, England

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 30期

关键词：

D O I：

10.1021/ja034705n

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Experimental kinetic data coupled with kinetic modeling implicates a tetrameric transition state in the Soai autocatalytic alkylation of pyrimidyl aldehydes. The kinetic model accurately predicts both the reaction rate and the amplification in enantiomeric excess observed in reactions carried out under a wide range of conditions. These studies reveal the Soai reaction to be an example of true autocatalytic efficiency in a template-directed minimal system" for self-replication. Copyright © 2003 American Chemical Society."

引用

页码：8978 / 8979

页数：2

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