Mitochondrial changes in endometrial carcinoma: Possible role in tumor diagnosis and prognosis (Review)

被引：28

作者：

Cormio, Antonella ^{[1
]}

Cormio, Gennaro ^{[2
,3
]}

Musicco, Clara ^{[4
]}

Sardanelli, Anna Maria ^{[5
,6
]}

Gasparre, Giuseppe ^{[7
]}

Gadaleta, Maria Nicola ^{[4
]}

机构：

[1] Univ Bari, Dept Biosci Biotechnol & Biopharmaceut, I-470125 Bari, Italy

[2] IRCCS Ist Oncol Giovanni Paolo 2, Gynecol Oncol Unit, Bari, Italy

[3] Univ Bari, Dept Biomed Sci & Med Oncol, I-470125 Bari, Italy

[4] CNR, Inst Biomembranes & Bioenerget, I-70126 Bari, Italy

[5] Univ Bari, Dept Basical Med Sci Neurosci & Sensory Organs, I-470125 Bari, Italy

[6] CNR, Inst Translat Pharmacol, Rome, Italy

[7] Univ Bologna, Unit Med Genet, Dept Med & Surg Sci, Bologna, Italy

来源：

ONCOLOGY REPORTS | 2015年 / 33卷 / 03期

关键词：

endometrial carcinoma; mitochondrial DNA mutations; mitochondrial biogenesis; prognostic and diagnostic markers; DNA MUTATIONS; COMPLEX-I; CANCER; CELLS; INSTABILITY; BIOGENESIS; GENERATION; TRANSCRIPTION; ORGANIZATION; PROGRESSION;

D O I：

10.3892/or.2014.3690

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Endometrial carcinoma (EC) is a solid neoplasia for which a role for mitochondria in cancer progression is currently emerging and yet represents a diagnostic and prognostic challenge. EC is one of the most frequently occurring gynecological malignancies in the Western world whose incidence has increased significantly during the last decades. Here, we review the literature data on mitochondrial changes reported in EC, namely, mitochondrial DNA (mtDNA) mutations, increase in mitochondrial biogenesis and discuss whether they may be used as new cancer biomarkers for early detection and prognosis of this cancer.

引用

页码：1011 / 1018

页数：8

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