Drug-Induced Cholestasis

被引：258

作者：

Padda, Manmeet S. ^{[3
]}

Sanchez, Mayra ^{[1
,2
]}

Akhtar, Abbasi J. ^{[4
]}

Boyer, James L. ^{[1
,2
]}

机构：

[1] Yale Univ, Sch Med, Dept Internal Med, Digest Dis Sect, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, Ctr Liver, New Haven, CT 06520 USA

[3] Centennial Hills Hosp Med Ctr, Div Gastroenterol, Las Vegas, NV USA

[4] Charles R Drew Univ Med & Sci, Div Gastroenterol, Los Angeles, CA 90059 USA

来源：

HEPATOLOGY | 2011年 / 53卷 / 04期

关键词：

SALT EXPORT PUMP; VANISHING BILE-DUCT; INDUCED LIVER-DISEASE; STEVENS-JOHNSON-SYNDROME; RAT HEPATOCYTE COUPLETS; ATP-BINDING-CASSETTE; CYCLOSPORINE-A; INTRAHEPATIC CHOLESTASIS; INDUCED HEPATOTOXICITY; INTERINDIVIDUAL VARIABILITY;

D O I：

10.1002/hep.24229

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Recent progress in understanding the molecular mechanisms of bile formation and cholestasis have led to new insights into the pathogenesis of drug-induced cholestasis. This review summarizes their variable clinical presentations, examines the role of transport proteins in hepatic drug clearance and toxicity, and addresses the increasing importance of genetic determinants, as well as practical aspects of diagnosis and management. (HEPATOLOGY 2011;53:1377-1387)

引用

页码：1377 / 1387

页数：11

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