Role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile X syndrome

被引：205

作者：

Dolen, Gul ^{[1
,2
]}

Bear, Mark F. ^{[1
]}

机构：

[1] MIT, Howard Hughes Med Inst, Picower Inst Learning & Memory, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA

[2] Brown Med Sch, Providence, RI USA

来源：

JOURNAL OF PHYSIOLOGY-LONDON | 2008年 / 586卷 / 06期

关键词：

D O I：

10.1113/jphysiol.2008.150722

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Metabotropic glutamate receptors (mGluRs) have been implicated in a diverse variety of neuronal functions. Studies reviewed here indicate that exaggerated signalling through mGluR5 can account for multiple cognitive and syndromic features of fragile X syndrome, the most common inherited form of mental retardation and autism. Since a reduction of mGluR5 signalling can reverse fragile X phenotypes, these studies provide a compelling rationale for the use of mGluR5 antagonists for the treatment of fragile X and related disorders.

引用

页码：1503 / 1508

页数：6

共 48 条

[1] The mGIuR theory of fragile X mental retardation [J].

Bear, MF ;

Huber, KM ;

Warren, ST .

TRENDS IN NEUROSCIENCES, 2004, 27 (07) :370-377

[2] Fmr1 KO mice as a possible model of autistic features [J].

Bernardet, Maude ;

Crusio, Wim E. .

THESCIENTIFICWORLDJOURNAL, 2006, 6 :1164-1176

[3] Metabotropic glutamate receptor mGlu5 is a mediator of appetite and energy balance in rats and mice [J].

Bradbury, MJ ;

Campbell, U ;

Giracello, D ;

Chapman, D ;

King, C ;

Tehrani, L ;

Cosford, NDP ;

Anderson, J ;

Varney, MA ;

Strack, AM .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2005, 313 (01) :395-402

[4] Anticonvulsant activity of two metabotropic glutamate Group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893) [J].

Chapman, AG ;

Nanan, K ;

Williams, M ;

Meldrum, BS .

NEUROPHARMACOLOGY, 2000, 39 (09) :1567-1574

[5] Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice [J].

Chiamulera, C ;

Epping-Jordan, MP ;

Zocchi, A ;

Marcon, C ;

Cottiny, C ;

Tacconi, S ;

Corsi, M ;

Orzi, F ;

Conquet, F .

NATURE NEUROSCIENCE, 2001, 4 (09) :873-874

[6] Abnormal dendritic spines in fragile X knockout mice: Maturation and pruning deficits [J].

Comery, TA ;

Harris, JB ;

Willems, PJ ;

Oostra, BA ;

Irwin, SA ;

Weiler, IJ ;

Greenough, WT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (10) :5401-5404

[7] Pharmacology and functions of metabotropic glutamate receptors [J].

Conn, PJ ;

Pin, JP .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1997, 37 :205-237

[8]

CONSORTIUM, 1994, CELL, V78, P23

[9] Fmr1 knockout mouse has a distinctive strain-specific learning impairment [J].

Dobkin, C ;

Rabe, A ;

Dumas, R ;

El Idrissi, A ;

Haubenstock, H ;

Brown, WT .

NEUROSCIENCE, 2000, 100 (02) :423-429

[10] Correction of fragile X syndrome in mice [J].

Dolen, Gul ;

Osterweil, Emily ;

Rao, B. S. Shankaranarayana ;

Smith, Gordon B. ;

Auerbach, Benjamin D. ;

Chattarji, Sumantra ;

Bear, Mark F. .

NEURON, 2007, 56 (06) :955-962

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