Innovative treatment programs against cancer -: II.: Nuclear factor-κB (NF-κB) as a molecular target

被引：98

作者：

Waddick, KG

Uckun, FM

机构：

[1] Hughes Inst, St Paul, MN 55113 USA

[2] Parker Hughes Canc Ctr, Biotherapy Program, St Paul, MN 55113 USA

[3] Parker Hughes Canc Ctr, Drug Discovery Program, St Paul, MN 55113 USA

来源：

BIOCHEMICAL PHARMACOLOGY | 1999年 / 57卷 / 01期

关键词：

signal transduction; cancer; apoptosis; molecular target; rational drug design;

D O I：

10.1016/S0006-2952(98)00224-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nuclear factor-kappa B (NF-kappa B) activity affects cell survival and determines the sensitivity of cancer cells to cytotoxic agents as well as to ionizing radiation. Preventing the protective function of NF-kappa B may result in chemo- and radio-sensitization of cancer cells. Therefore, NF-kappa B has emerged as one of the most promising molecular targets in rational drug design efforts of translational cancer research programs. (C) 1998 Elsevier Science Inc.

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页码：9 / 17

页数：9

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