Synthesis and in vitro cholesterol dissolution by 23-and 24-phosphonobile acids

被引：18

作者：

Babu, P ^{[1
]}

Maitra, U ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India

来源：

STEROIDS | 2005年 / 70卷 / 10期

关键词：

bile acids; cholesterol dissolution; gallstone dissolution; phosphonobile acids;

D O I：

10.1016/j.steroids.2005.03.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new class of 23- and 24-phosphonobile acids have been synthesized from bile acid and their in vitro cholesterol-dissolving efficiency have been estimated. 24-Phosphonobile salts (PBSs) are slightly more efficient in solubilizing cholesterol than 23-PBSs and natural bile salts. The cholesterol solubilizing power is influenced by the structure of PBSs, and is considerably reduced with an increase in the bulk pH. ((c) 2005 Elsevier Inc. All rights reserved.

引用

页码：681 / 689

页数：9

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