Delivery of tea polyphenols to the oral cavity by green tea leaves and black tea extract

被引:99
作者
Lee, MJ
Lambert, JD
Prabhu, S
Meng, XF
Lu, H
Maliakal, P
Ho, CT
Yang, CS
机构
[1] Rutgers State Univ, Ernest Mario Sch Pharm, Dept Biol Chem, Piscataway, NJ 08854 USA
[2] Rutgers State Univ, Cook Coll, Dept Food Sci, New Brunswick, NJ 08903 USA
关键词
D O I
10.1158/1055-9965.EPI-03-0040
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Catechins and theaflavins, polyphenolic compounds derived from tea (Camellia sinensis, fam. Theaceae), have been reported to have a wide range of biological activities including prevention of tooth decay and oral cancer. The present study was undertaken to determine the usefulness of green tea leaves and black tea extract for the delivery of catechins and theaflavins to the oral cavity. After holding either green tea leaves (2 g) or brewed black tea (2 g of black tea leaves in 100 ml) in the mouth for 2-5 min and thoroughly rinsing the mouth, high concentrations of catechins (C-max = 131.0-2.2 mum) and theaflavins (C-max = 1.8-0.6 mum) were observed in saliva in the 1st hour. Whereas there was significant interindividual variation in the peak levels of catechins and theaflavins, the overall kinetic profile was similar, with t(1/2) = 25-44 min and 49-76 min for catechins and theaflavins, respectively (average coefficient of variation in t(1/2) was 23.4%). In addition to the parent catechin and theaflavin peaks, five unidentified peaks were also observed in saliva after black tea treatment. Hydrolysis of theaflavin gallates, apparently by salivary esterases, was observed in vitro and in vivo. These results indicate that tea leaves can be used as a convenient, slow-release source of catechins and theaflavins and provide information for the possible use of tea in the prevention of oral cancer and dental caries.
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页码:132 / 137
页数:6
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