Signet ring cell adenocarcinoma of the lung with an EML4-ALK fusion gene mimicking mucinous (colloid) adenocarcinoma: A case report

被引：4

作者：

Ohba, Taro ^{[1
]}

Sugio, Kenji ^{[1
]}

Kometani, Takuro ^{[1
]}

Yamaguchi, Masafumi ^{[1
]}

Hamatake, Motoharu ^{[1
]}

Nosaki, Kaname ^{[1
]}

Takeoka, Hiroaki ^{[1
]}

Kitajima, Hiromoto ^{[1
]}

Hirai, Fumihiko ^{[1
]}

Seto, Takashi ^{[1
]}

Taguchi, Kenichi ^{[2
]}

Nishiyama, Kenichi ^{[2
]}

Shida, Yoshitaka ^{[3
]}

Ichinose, Yukito ^{[1
]}

机构：

[1] Kyushu Natl Canc Ctr, Dept Thorac Oncol, Minami Ku, Fukuoka 8111395, Japan

[2] Kyushu Natl Canc Ctr, Canc Pathol Lab, Inst Clin Res, Fukuoka 8111395, Japan

[3] Kyushu Natl Canc Ctr, Dept Radiol, Fukuoka 8111395, Japan

来源：

LUNG CANCER | 2011年 / 73卷 / 03期

关键词：

Signet ring cell carcinoma; EML4-ALK; Non-small cell lung cancer; Surgery; Multiplex RT-PCR; Histopathology; CANCER; MUTATIONS; KINASE; GEFITINIB; FEATURES;

D O I：

10.1016/j.lungcan.2011.05.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

We herein report a case of signet ring cell adenocarcinoma of the lung with an EML4-ALK fusion gene mimicking mucinous (colloid) adenocarcinoma. A 79-year-old female presented with a pulmonary tumor located in the right lower lobe measuring 21 mm in size. A right lower lobectomy was performed. The postoperative pathological examination revealed signet ring cell carcinoma with abundant mucin pools, and a multiplex RT-PCR analysis revealed the variant 2 inversion of the EML4-ALK gene. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：375 / 378

页数：4

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