Somatic gene and cell therapy strategies for the treatment of cardiac arrhythmias

被引:24
作者
Gepstein, L
Feld, Y
Yankelson, L
机构
[1] Technion Israel Inst Technol, Bruce Rappaport Fac Med, Cardiovasc Res Lab, Rappaport Family Inst Res Med Sci, IL-31096 Haifa, Israel
[2] Rambam Med Ctr, IL-31096 Haifa, Israel
来源
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 2004年 / 286卷 / 03期
关键词
D O I
10.1152/ajpheart.00962.2003
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:H815 / H822
页数:8
相关论文
共 45 条
[1]   ALTERATIONS OF K+ CURRENTS IN ISOLATED HUMAN VENTRICULAR MYOCYTES FROM PATIENTS WITH TERMINAL HEART-FAILURE [J].
BEUCKELMANN, DJ ;
NABAUER, M ;
ERDMANN, E .
CIRCULATION RESEARCH, 1993, 73 (02) :379-385
[2]   The incorporation of an ion channel gene mutation associated with the long QT syndrome (Q9E-hMiRP1) in a plasmid vector for site-specific arrhythmia gene therapy:: In vitro and in vivo feasibility studies [J].
Burton, DY ;
Song, CX ;
Fishbein, I ;
Hazelwood, S ;
Li, Q ;
Defelice, S ;
Connolly, JM ;
Perlstein, I ;
Coulter, DA ;
Levy, RJ .
HUMAN GENE THERAPY, 2003, 14 (09) :907-922
[3]   SERCA2a overexpression decreases the incidence of aftercontractions in adult rabbit ventricular myocytes [J].
Davia, K ;
Bernobich, E ;
Ranu, HK ;
del Monte, F ;
Terracciano, CMN ;
MacLeod, KT ;
Adamson, DL ;
Chaudhri, B ;
Hajjar, RJ ;
Harding, SE .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2001, 33 (05) :1005-1015
[4]  
Donahue JK, 2000, NAT MED, V6, P1395
[5]   MORTALITY AND MORBIDITY IN PATIENTS RECEIVING ENCAINIDE, FLECAINIDE, OR PLACEBO - THE CARDIAC-ARRHYTHMIA SUPPRESSION TRIAL [J].
ECHT, DS ;
LIEBSON, PR ;
MITCHELL, LB ;
PETERS, RW ;
OBIASMANNO, D ;
BARKER, AH ;
ARENSBERG, D ;
BAKER, A ;
FRIEDMAN, L ;
GREENE, HL ;
HUTHER, ML ;
RICHARDSON, DW .
NEW ENGLAND JOURNAL OF MEDICINE, 1991, 324 (12) :781-788
[6]   Enhancement of murine cardiac chronotropy by the molecular transfer of the human β2 adrenergic receptor cDNA [J].
Edelberg, JM ;
Aird, WC ;
Rosenberg, RD .
JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (02) :337-343
[7]   Molecular enhancement of porcine cardiac chronotropy [J].
Edelberg, JM ;
Huang, DT ;
Josephson, ME ;
Rosenberg, RD .
HEART, 2001, 86 (05) :559-562
[8]   Dual gene therapy with SERCA1 and Kir2.1 abbreviates excitation without suppressing contractility [J].
Ennis, IL ;
Li, RA ;
Murphy, AM ;
Marbán, E ;
Nuss, HB .
JOURNAL OF CLINICAL INVESTIGATION, 2002, 109 (03) :393-400
[9]   Anisotropic activation spread in heart cell monolayers assessed by high-resolution optical mapping - Role of tissue discontinuities [J].
Fast, VG ;
Darrow, BJ ;
Saffitz, JE ;
Kleber, AG .
CIRCULATION RESEARCH, 1996, 79 (01) :115-127
[10]   Electrophysiological modulation of cardiomyocytic tissue by transfected fibroblasts expressing potassium channels - A novel strategy to manipulate excitability [J].
Feld, Y ;
Melamed-Frank, M ;
Kehat, Z ;
Tal, D ;
Marom, S ;
Gepstein, L .
CIRCULATION, 2002, 105 (04) :522-529