Comparison of pneumococcal conjugate polysaccharide and free polysaccharide vaccines in elderly adults:: Conjugate vaccine elicits improved antibacterial immune responses and immunological memory

被引：200

作者：

de Roux, Andres ^{[1
]}

Schmoeele-Thoma, B. ^{[4
]}

Siber, G. R. ^{[6
]}

Hackell, J. G. ^{[6
]}

Kuhnke, A. ^{[2
]}

Ahlers, N. ^{[4
]}

Baker, S. A. ^{[6
]}

Razmpour, A. ^{[6
]}

Emini, E. A. ^{[6
]}

Fernsten, P. D. ^{[6
]}

Gruber, W. C. ^{[6
]}

Lockhart, S. ^{[6
]}

Burkhardt, O. ^{[5
]}

Welte, T. ^{[5
]}

Lode, H. M. ^{[3
]}

机构：

[1] Charite Univ Med Berlin, Ctr Resp Med Charlottenburg Castle, D-14059 Berlin, Germany

[2] Charite Univ Med Berlin, Dept Resp Med Charite, D-14059 Berlin, Germany

[3] Charite Univ Med Berlin, Res Ctr Med Studies, Inst Clin Pharmacol, D-14059 Berlin, Germany

[4] Wyeth Pharma, Wyeth Vaccines Res, Munster, Germany

[5] Hannover Med Sch, Dept Chest Dis, D-30623 Hannover, Germany

[6] Wyeth, Wyeth Vaccines Res, Pearl River, NY USA

来源：

CLINICAL INFECTIOUS DISEASES | 2008年 / 46卷 / 07期

关键词：

D O I：

10.1086/529142

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background. High functional antibody responses, establishment of immunologic memory, and unambiguous efficacy in infants suggest that an initial dose of conjugated pneumococcal polysaccharide (PnC) vaccine may be of value in a comprehensive adult immunization strategy. Methods. We compared the immunogenicity and safety of 7-valent PnC vaccine (7vPnC) with that of 23-valent pneumococcal polysaccharide vaccine (PPV) in adults >= 70 years of age who had not been previously vaccinated with a pneumococcal vaccine. One year later, 7vPnC recipients received a booster dose of either 7vPnC (the 7vPnC/7vPnC group) or PPV (the 7vPnC/PPV group), and PPV recipients received a booster dose of 7vPnC (the PPV/7vPnC group). Immune responses were compared for each of the 7 serotypes common to both vaccines. Results. Antipolysaccharide enzyme-linked immunosorbent assay antibody concentrations and opsonophagocytic assay titers to the initial dose of 7vPnC were significantly greater than those to the initial dose of PPV for 6 and 5 of 7 serotypes, respectively (P < .01 and P < .05, respectively). 7vPnC/7vPnC induced antibody responses that were similar to those after the first 7vPnC inoculation, and 7vPnC/PPV induced antibody responses that were similar to or greater than antibody responses after administration of PPV alone; PPV/7vPnC induced significantly lower antibacterial responses, compared with those induced by 7vPnC alone, for all serotypes (P < .05). Conclusion. In adults, an initial dose of 7vPnC is likely to elicit higher and potentially more effective levels of antipneumococcal antibodies than is PPV. In contrast with PPV, for which the induction of hyporesponsiveness was observed when used as a priming dose, 7vPnC elicits an immunological state that permits subsequent administration of 7vPnC or PPV to maintain functional antipolysaccharide antibody levels.

引用

页码：1015 / 1023

页数：9

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