VEGF: a critical player in neurodegeneration

被引：188

作者：

Storkebaum, E ^{[1
]}

Carmeliet, P ^{[1
]}

机构：

[1] Univ Leuven VIB, Ctr Transgene Technol & Gene Therapy, B-3000 Leuven, Belgium

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2004年 / 113卷 / 01期

关键词：

D O I：

10.1172/JCI200420682

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

VEGF is a prototype angiogenic factor, but recent evidence indicates that this growth factor also has direct effects on neural cells. Abnormal regulation of VEGF expression has now been implicated in several neurodegenerative disorders, including motoneuron degeneration. This has stimulated an increasing interest in assessing the therapeutic potential of VEGF as a neuroprotective agent for such neuro degenerative disorders.

引用

页码：14 / 18

页数：5

共 57 条

[1] LEARNING CAUSES SYNAPTOGENESIS, WHEREAS MOTOR-ACTIVITY CAUSES ANGIOGENESIS, IN CEREBELLAR CORTEX OF ADULT-RATS
BLACK, JE
ISAACS, KR
ANDERSON, BJ
ALCANTARA, AA
GREENOUGH, WT
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (14) : 5568 - 5572
[2] Diabetic neuropathy
Boulton, AJM
Malik, RA
[J]. MEDICAL CLINICS OF NORTH AMERICA, 1998, 82 (04) : 909 - +
[3] Effect of age on cerebral blood flow: Measurement with ungated two-dimensional phase-contrast MR angiography in 250 adults
Buijs, PC
Krabbe-Hartkamp, MJ
Bakker, CJG
de Lange, EE
Ramos, LMP
Breteler, MMB
Mali, WPTM
[J]. RADIOLOGY, 1998, 209 (03) : 667 - 674
[4] Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
Carmeliet, P
Ferreira, V
Breier, G
Pollefeyt, S
Kieckens, L
Gertsenstein, M
Fahrig, M
Vandenhoeck, A
Harpal, K
Eberhardt, C
Declercq, C
Pawling, J
Moons, L
Collen, D
Risau, W
Nagy, A
[J]. NATURE, 1996, 380 (6573) : 435 - 439
[5] Angiogenesis in health and disease
Carmeliet, P
[J]. NATURE MEDICINE, 2003, 9 (06) : 653 - 660
[6] From Charcot to Lou Gehrig: Deciphering selective motor neuron death in ALS
Cleveland, DW
Rothstein, JD
[J]. NATURE REVIEWS NEUROSCIENCE, 2001, 2 (11) : 806 - 819
[7] CROLL SD, 2003, IN PRESS RECENT ADV
[8] Vasomotor hyporeactivity in the anterior cerebral artery during motor activation in Huntington's disease patients
Deckel, AW
Duffy, JD
[J]. BRAIN RESEARCH, 2000, 872 (1-2) : 258 - 261
[9] Promotion of regeneration of corticospinal tract axons in rats with recombinant vascular endothelial growth factor alone and combined with adenovirus coding for this factor
Facchiano, F
Fernandez, E
Mancarella, S
Maira, G
Miscusi, M
D'Arcangelo, D
Cimino-Reale, G
Falchetti, ML
Capogrossi, MC
Pallini, R
[J]. JOURNAL OF NEUROSURGERY, 2002, 97 (01) : 161 - 168
[10] Pathological features of cerebral cortical capillaries are doubled in Alzheimer's disease and Parkinson's disease
Farkas, E
De Jong, GI
de Vos, RAI
Steur, ENHJ
Luiten, PGM
[J]. ACTA NEUROPATHOLOGICA, 2000, 100 (04) : 395 - 402

← 1 2 3 4 5 6 →