Does More Accurate Exposure Prediction Necessarily Improve Health Effect Estimates?

被引:88
作者
Szpiro, Adam A. [1 ]
Paciorek, Christopher J. [2 ,3 ]
Sheppard, Lianne [1 ,4 ]
机构
[1] Univ Washington, Dept Biostat, Seattle, WA 98195 USA
[2] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA
[3] Univ Calif Berkeley, Dept Stat, Berkeley, CA 94720 USA
[4] Univ Washington, Dept Environm & Occupat Hlth Sci, Seattle, WA 98195 USA
基金
美国国家环境保护局;
关键词
AIR-POLLUTION; LONG;
D O I
10.1097/EDE.0b013e3182254cc6
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
A unique challenge in air pollution cohort studies and similar applications in environmental epidemiology is that exposure is not measured directly at subjects' locations. Instead, pollution data from monitoring stations at some distance from the study subjects are used to predict exposures, and these predicted exposures are used to estimate the health effect parameter of interest. It is usually assumed that minimizing the error in predicting the true exposure will improve health effect estimation. We show in a simulation study that this is not always the case. We interpret our results in light of recently developed statistical theory for measurement error, and we discuss implications for the design and analysis of epidemiologic research. (Epidemiology 2011; 22: 680-685)
引用
收藏
页码:680 / 685
页数:6
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