Inhibitory effect of losartan on laser-induced choroidal neovascularization in rats

被引：24

作者：

Hikichi, T ^{[1
]}

Mori, F ^{[1
]}

Takamiya, A ^{[1
]}

Sasaki, M ^{[1
]}

Horikawa, Y ^{[1
]}

Takeda, M ^{[1
]}

Yoshida, A ^{[1
]}

机构：

[1] Asahikawa Med Coll, Dept Ophthalmol, Asahikawa, Hokkaido 0788510, Japan

来源：

AMERICAN JOURNAL OF OPHTHALMOLOGY | 2001年 / 132卷 / 04期

关键词：

D O I：

10.1016/S0002-9394(01)01139-4

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

METHODS: Experimental study. Fifteen Brown-Norway male rats received losartan (approximately 5 mg/kg/d) in drinking water, and 15 Brown-Norway male rats re, ceived unsupplemented drinking water 1 week before photocoagulation, and it was continued to the end of the study. Two weeks after intense laser photocoagulation, choroidal neovascularization was evaluated by fluorescein angiography and histopathologic evaluation. RESULTS: The incidence of choroidal neovascularization formation was 99.5 +/- .2% (mean +/- standard deviation) in controls and 72.5 +/- 8.8% in losartan-treated rats (P < .01). Quantitative morphometric assessment revealed mean choroidal neovascularization lesion thick, ness of 54 and 44.8 mum, respectively, in controls and losartan-treated rats (P < .01). CONCLUSION: Losartan seems to inhibit development of laser-induced choroidal neovascularization. Angiotensin receptor antagonists may be useful as prophylaxis against choroidal neovascularization associated with age-related macular degeneration. (C) 2001 by Elsevier Science Inc. All rights reserved.

引用

页码：587 / 589

页数：3

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