Remote ischaemic preconditioning: underlying mechanisms and clinical application

被引：437

作者：

Hausenloy, Derek J.

Yellon, Derek M.

机构：

[1] Hatter Cardiovascular Institute, University College London Hospital and Medical School, London WC1E 6HX

来源：

CARDIOVASCULAR RESEARCH | 2008年 / 79卷 / 03期

关键词：

D O I：

10.1093/cvr/cvn114

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Remote ischaemic preconditioning (RIPC) represents a strategy for harnessing the body's endogenous protective capabilities against the injury incurred by ischaemia and reperfusion. It describes the intriguing phenomenon in which transient non-lethal ischaemia and reperfusion of one organ or tissue confers resistance to a subsequent episode of lethal ischaemia reperfusion injury in a remote organ or tissue. In its original conception, it described intramyocardial protection, which could be relayed from the myocardium served by one coronary artery to another. It soon became apparent that myocardial infarct size could be dramatically reduced by applying brief ischaemia and reperfusion to an organ or tissue remote from the heart before the onset of myocardial infarction. The concept of remote organ protection has now been extended beyond that of solely protecting the heart to providing a general form of inter-organ protection against ischaemia-reperfusion injury. This article reviews the history and evolution of the phenomenon that is RIPC, the potential mechanistic pathways underlying its cardioprotective effect, and its emerging application in the clinical setting. © The Author 2008.

引用

页码：377 / 386

页数：10

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