Mitochondrial regulation of oxygen sensing

被引：129

作者：

Bell, EL ^{[1
]}

Emerling, BM ^{[1
]}

Chandel, NS ^{[1
]}

机构：

[1] Northwestern Univ, Dept Med, Div Pulm & Crit Care Med, Chicago, IL 60601 USA

来源：

MITOCHONDRION | 2005年 / 5卷 / 05期

关键词：

mitochondria; oxygen sensing; HIF-1; angiogenesis; hypoxia;

D O I：

10.1016/j.mito.2005.06.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Maintenance of oxygen homoeostasis is required for the survival of higher organisms. The transcription factor hypoxia inducible factor (HIF) has a crucial role in oxygen homoeostasis by integrating the decrease in oxygen levels to increase hypoxic gene expression. How cells sense decrease in oxygen levels to elicit an increase in HIF dependent gene expression is not fully understood. In this review, we discuss the role of mitochondria as oxygen sensors regulating HIF. (c) 2005 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

引用

页码：322 / 332

页数：11

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