Brownian modulated optical nanoprobes

被引：73

作者：

Behrend, CJ ^{[1
]}

Anker, JN ^{[1
]}

Kopelman, R ^{[1
]}

机构：

[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

来源：

APPLIED PHYSICS LETTERS | 2004年 / 84卷 / 01期

关键词：

D O I：

10.1063/1.1637963

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

Brownian modulated optical nanoprobes (Brownian MOONs) are fluorescent micro- and nanoparticles that resemble moons: one hemisphere emits a bright fluorescent signal, while an opaque metal darkens the other hemisphere. Brownian motion causes the particles to tumble and blink erratically as they rotate literally through the phases of the moon. The fluctuating probe signals are separated from optical and electronic backgrounds using principal components analysis or images analysis. Brownian MOONs enable microrheological measurements on size scales and timescales that are difficult to study with other methods. Local chemical concentrations can be measured simultaneously, using spectral characteristics of indicator dyes embedded within the MOONs. (C) 2004 American Institute of Physics.

引用

页码：154 / 156

页数：3

共 26 条

[1] Aspherical magnetically modulated optical nanoprobes (MagMOONs) [J].